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. 2016 Dec 9;6(2):110–119. doi: 10.1002/psp4.12144

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© 2016 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Pediatric physiologically based pharmacokinetic (PBPK) model predicted vs. observed concentration‐time profiles of morphine in children. The simulation of morphine concentration‐time profile was conducted for each organic cation transporter (OCT1) genotype (a) for wild *1/*1 type, (b) for *1/*2 heterozygous, (c) for *1/*3 heterozygous, (d) for *2/*3 homozygous, and (e) for all OCT1 genotype tested in this study with time range up to 24 hours, according to the Method section. The simulation results shown in a to d were overlaid with observed data (open circles).7 Solid and dashed lines represent the mean and 5th/95th percentiles of simulation results, respectively.