Table 1.
Metabolic pathways perturbed during plasma separation delays.
| Subpathway | # perturbed analytesa |
% of total |
p-Valueb |
|---|---|---|---|
| Polyunsaturated fatty acid (n3 and n6) | 9/14 | 64% | 0.0002 |
| Glycolysis, gluconeogenesis, and pyruvate metabolism |
4/5 | 80% | 0.0047 |
| Long chain fatty acid | 7/14 | 50% | 0.0058 |
| TCA cycle | 4/6 | 67% | 0.0115 |
| Gamma-glutamyl amino acid | 5/9 | 56% | 0.0118 |
| Phospholipid metabolism | 3/4 | 75% | 0.0205 |
| Alanine and aspartate metabolism | 3/4 | 75% | 0.0205 |
| Methionine, cysteine, SAM and taurine metabolism |
6/14 | 43% | 0.023 |
| Ketone bodies | 2/2 | 100% | 0.0342 |
| Endocannabinoid | 2/2 | 100% | 0.0342 |
| Glutathione metabolism | 2/2 | 100% | 0.0342 |
| Purine metabolism, (hypo)xanthine/inosine containing |
3/6 | 50% | 0.0686 |
a
Total number of subpathway analytes significantly perturbed during the 0 to 20 h time course over the total number of analytes detected in the subpathway.
b
Calculated using a Fisher's exact test.