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. 2016 Nov 3;52:78–92. doi: 10.1540/jsmr.52.78

Fig. 4.

Fig. 4.

Hypothetical TRPC4- / TRPC6-mediated signaling pathway downstream of TGF-β1 in InMyoFib cells. TRPC6 interacted directly with α-SMA, N-cadherin, activating its expression, and indirectly supported α-SMA, N-cadherin expression by downregulating the negative regulators COL1A1, IL-10, and IL-11. The TRPC6 channel negatively regulates COL1A1, IL-10, and IL-11 expression, as well as Smad-2, ERK, and p38-MAPK phosphorylation in intestinal myofibroblasts. AKT signal transduction may involve TRPC6 upregulation downstream of the TGF-β1 receptors.