Figure 1.

A) Results of whole-brain vertex-wise analysis evaluating the differential association between peak VO₂ (CRF) and cortical thickness (CT) in older (OA) versus young adults (YA), controlling for sex and education. Results that survived a cluster-based correction for multiple comparisons (clusterwise threshold of p<0.05) are outlined in green and include the left SMG. Blue color scale represents interaction effects where peak VO₂ and cortical thickness were positively correlated in OA and negatively associated in YA. The opposite pattern was observed in the right CNG, although within-group correlations between CRF and thickness were not significant in follow-up partial correlations. B) Scatterplots visualizing association of cortical thickness and peak VO₂ by Age Group. Note: CNG= cingulate; lOFC=lateral orbitofrontal cortex; MTC=middle temporal cortex; PCC= Paracentral/Posterior Cingulate Cortex; PCN=Precuneus; PHG= parahippocampal gyrus; PrC= Precentral Cortex; SMG= supramarginal gyrus; sPFC= Superior Prefrontal Cortex;