Table 1.
Baseline Characteristics Study Cohorts
| AGES (n=2953) |
ARIC (n=9276) |
FHS (n=7509) |
PREVEND (n=3515) |
RS-I (n=5729) |
RS-II (n=2087) |
WGHS (n=20577) |
|
|---|---|---|---|---|---|---|---|
| Age, years | 76 (5) | 54 (6) | 51 (15) | 49 (12) | 69 (9) | 65 (8) | 54 (7) |
| Men | 1341 (42%) | 4356 (47%) | 3459 (46%) | 1809 (51%) | 2302 (40%) | 949 (46%) | - |
| Height, cm | 167 (9) | 169 (9) | 169 (10) | 174 (9) | 167 (9) | 170 (9) | 164 (6) |
| Current cigarette smoking | 378 (13%) | 2293 (25%) | 1183 (16%) | 1235 (35%) | 1324 (23%) | 470 (23%) | 2315 (11%) |
| Body mass index, kg/m2 | 27.1 (4.4) | 27.0 (4.9) | 27.0 (5.1) | 26.1 (4.2) | 26.3 (3.7) | 27.2 (4.0) | 25.9 (4.9) |
| SBP, mmHg | 143 (20) | 118 (17) | 123 (18) | 129 (20) | 139 (22) | 143 (21) | 123 (14) |
| DBP, mmHg | 74 (10) | 72 (10) | 75 (10) | 74 (10) | 74 (11) | 79 (11) | 77 (9) |
| Hypertensive medication | 1834 (62%) | 2344 (25%) | 1578 (21%) | 416 (14%) | 1730 (30%) | 566 (27%) | 2610 (13%) |
| Diabetes mellitus | 326 (11%) | 795 (9%) | 443 (6%) | 133 (4%) | 571 (10%) | 219 (11%) | 497 (2%) |
| Previous heart failure | 49 (2%) | 334 (4%) | 40 (0.5%) | 6 (0.2%) | 139 (2%) | 18 (1%) | - |
| Previous coronary heart disease | 495 (17%) | 454 (5%) | 419 (6%) | 28 (1%) | 431 (8%) | 128 (6%) | - |
| EtOH Consumption ≥ 2 drinks/day | 23 (1%) | 594 (6%) | 7243 (96%)* | 943 (27%)† | 916 (16%) | 390 (19%) | 838 (4%) |
| Body mass index gene score | 4.1 (0.5) | 4.1 (0.5) | 4.1 (0.5) | 4.1 (0.5) | 4.1 (0.5) | 4.1 (0.5) | 4.1 (0.5) |
| FTO variant (rs1558902) CAF, % | 40 | 41 | 42 | 40 | 38 | 40 | 41 |
| # Atrial fibrillation cases | 422 (14%) | 1373 (15%) | 555 (7%) | 113 (3%) | 693 (12%) | 80 (4%) | 942 (5%) |
| Mean follow-up time, years | 7.4 (2.5) | 19.2 (5.5) | 8.4 (3.2) | 9.6 (2.3) | 12.7 (5.7) | 8.4 (1.9) | 18.0 (3.3) |
| Baseline years | 2002-2006 | 1987-1989 | 1987-2007 | 1997-1998 | 1990-93 | 2000-01 | 1992 - 1995 |
| End of follow-up | 2012 | 2010 | 2011 | 2008 | 2010 | 2010 | 2011 |
Values correspond to N (%) or mean (standard deviation). Body mass index (BMI) gene score reflects a weighted sum of BMI increasing alleles of 39 single nucleotide polymorphisms (see Methods).
*
>0 drinks/day;
†
≥1 drink/day.
AGES, indicates the Age, Gene/Environment Susceptibility—Reykjavik study; ARIC, Atherosclerosis Risk in Communities; FHS, Framingham Heart Study; PREVEND, Prevention of Renal and Vascular End-Stage Disease; RS, Rotterdam Study; WGHS, Women's Genome Health Study; SBP, systolic blood pressure; DBP, diastolic blood pressure; EtOH, alcohol; CAF, coded allele frequency for FTO SNP (rs1558902) associated with increasing body mass index.