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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: J Immunol. 2017 Jan 27;198(5):1995–2005. doi: 10.4049/jimmunol.1601425

Figure 8. Gene expression from IL21 signaling pathway in Pre-vaccination pTfh correlates with post-vaccination serological and immunological responses to Influenza vaccination.

Figure 8

X-Y plots show linear regression of A) IL21R expression (without stimulation) and B) Delta IL21 expression in pTfh (as determined by Delta= [Et_H1N1] − [Et_Unstim]) with H1N1 Spots T1/million PBMC (left), H1N1 Titer T1 (middle), and H1N1 Titer T1/T0 (right). R- and p-values are shown on the graphs, open circles designate non-responders while closed circles designate responders. C) IL-21 plasma levels before (T0) and after influenza vaccination (T1) in HIV+ responders and non-responders.