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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: J Trauma Acute Care Surg. 2017 Mar;82(3):557–565. doi: 10.1097/TA.0000000000001338

Figure 3. The role of oxygen and iron in HIF1α degradation.

Figure 3

(A), In the presence of normoxia and iron abundance, HIF1α undergoes hydroxylation by active form of prolyl hydroxylase, which requires oxygen and iron cofactors. This is followed by proteasomal degradation of HIF1α mediated by ubiquitin ligase. (B), Limitation of oxygen and iron, characteristic of injured and ischemic tissues, are essential for post-translational HIF1α stabilization and accumulation, affecting gene transcription.