Figure 4.

Biophysical models include explicit equations for all the components influencing neurorehabilitation dynamics. The equation summarizes a formalism in which the change of a cell voltage in time is equal to a non-linear function of the voltage itself and the state of intrinsic currents, summed to incoming synaptic currents. The formalism builds on Hodgkin–Huxley equations (89), which relate the dynamics of transmembrane channels in time (which will have their own equations) and how voltage changes in time. Intrinsic currents and synaptic currents (each with their own equations and variables) can be added once the formalism is in place. The arrows emphasize where in the biophysical model the role of behavior, synaptic plasticity, and stimulation can be included.