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. 2017 Feb 23;8:58. doi: 10.3389/fneur.2017.00058

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Copyright © 2017 Malerba, Straudi, Fregni, Bazhenov and Basaglia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Biophysical models of cortical layers include excitatory and inhibitory cells and synapses. In the diagram, pyramidal cells are represented as triangles and basket cells are circles. Arrows represent excitatory connections (which can be AMPA or NMDA receptor mediated) and inhibitory (GABAergic) connections. The equation shows the basic principle on which the network model is constructed: each cell voltage changes in time according to the combined effect of intrinsic (voltage-dependent) currents and synaptic currents.