Table 2. Unadjusted and adjusted odds ratios (OR), 95% confidence intervals (CI) of maternal clinical factors for postcesarean maternal infection, n=2013.
| Maternal Characteristic | Unadjusted OR (95% CI) | Adjusted OR* (95% CI) |
|---|---|---|
|
| ||
| Azithromycin assignment | 0.5 (0.3-0.6) | 0.4 (0.3-0.6) |
|
| ||
| Age, (years, mean ± SD) | 0.95 (0.93-0.98) | 0.95 (0.93-0.98) |
|
| ||
| Hispanic and Other | 1.4 (0.9-2.1) | 1.4 (0.9-2.2) |
| Black | 2.0 (1.4-3.0) | 1.9 (1.3-2.8) |
| White | Ref | Ref |
|
| ||
| Body Mass Index ≥ 30 kg/m2 | 2.5 (0.9-6.9) | |
| Body Mass Index 25-30 kg/m2 | 1.5 (0.5-4.5) | |
| Body Mass Index < 25 kg/m2 | Ref | - |
|
| ||
| Private Pay | 0.5 (0.4-0.8) | - |
|
| ||
| Pregestational diabetes | 1.6 (0.8-3.1) | |
| Gestational diabetes | 0.7 (0.4-1.3) | |
| No diabetes | Ref | - |
|
| ||
| Smoker | 1.1 (0.7-1.8) | - |
|
| ||
| Group B Streptococci colonization | 0.7 (0.5-1.0) | - |
|
| ||
| Preterm delivery < 37 weeks | 0.94 (0.57-1.6) | - |
|
| ||
| Primary cesarean | 1.5 (0.97-2.1) | - |
|
| ||
| Intrauterine pressure catheter use | 2.3 (1.6-3.3) | - |
|
| ||
| Nontransverse uterine incision | 1.8 (0.9-3.4) | 2.0 (1.03-4.0) |
|
| ||
| Vertical skin incision | 2.1 (1.1-3.9) | - |
|
| ||
| Induced labor | 1.6 (1.2-2.3) | - |
|
| ||
| Steroids for any reason | 1.1 (0.7-2.0) | - |
|
| ||
| Steroids for lung maturity | 1.4 (0.7-2.6) | - |
|
| ||
| Steroids for all other reasons | 0.7 (0.2-1.9) | - |
|
| ||
| Amnioinfusion | 1.0 (0.7-1.6) | - |
|
| ||
| Duration of membrane rupture | ||
| ≤ 6 hours | Ref | Ref |
| > 6 - 12 hours | 1.9 (1.2-3.0) | 1.9 (1.2-3.1) |
| > 12 - 18 hours | 2.3 (1.4-3.7) | 2.5 (1.5-4.1) |
| > 18 -24 hours | 3.3 (2.0-5.7) | 3.7 (2.1-6.4) |
| > 24 hours | 2.4 (1.2-4.8) | 2.7 (1.4-5.5) |
|
| ||
| Surgery Duration | ||
| ≤ 38 minutes | Ref | Ref |
| 39 - 49 minutes | 1.3 (0.8-2.2) | 1.5 (0.9-2.5) |
| > 49 - 60 minutes | 1.9 (1.2-2.9) | 2.0 (1.3-3.2) |
| > 60 minutes | 1.8 (1.2-2.9) | 2.1 (1.3-3.4) |
|
| ||
| Skin Closure (significant interaction with treatment) | ||
| For azithromycin group: | ||
| Staples/topical skin adhesive | 0.44 (0.3-0.8) | - |
| Sutures | Ref | |
| For placebo group: | 1.48 (1.01-2.2) | |
| Staples/topical skin adhesive | Ref | - |
| Sutures | ||
*
Adjusted for age, race/ethnicity, membrane rupture and surgery duration, non-transverse uterine incision, and assignment to azithromycin