Table 1.
Cellular immunofluorescence (# cells per mm2 or % co-expression) in NAc core, PrL and IL from rats euthanized 45 min or 72 hr after the last saline or nicotine self-administration session. Values represent mean ± SEM. N=6-8 rats per group.
| NAc core | 45 min | 72 hr | ||
|---|---|---|---|---|
| Saline | Nicotine | Saline | Nicotine | |
| # c-Fos+ cells | 44.6 ± 5.1 | 58.1 ± 4.2* | 25.7 ± 3.7 | 26 ± 2.3 |
| # pDARPP32+ cells | 105.8 ± 8.5 | 115.9 ± 6.9 | 95.3 ± 0.6 | 96.9 ± 4.2 |
| % pDARPP32+ cells co-expressing c-Fos | 45.1 ± 0.9 | 51.9 ± 1.9 | 55.3 ± 2.8 | 52.9 ± 1.7 |
| PrL | 45 min | 72 hr | ||
| Saline | Nicotine | Saline | Nicotine | |
| # PRV+ cells | 20.1 ±1.9 | 19.8 ±0.7 | 11.8 ± 1.5 | 15.5 ± 0.8 |
| # WFA+ cells | 8.7 ±0.9 | 7.0 ±0.6 | 7.1 ± 0.7 | 10.1 ± 0.6 |
| # c-Fos+ cells | 37.5 ± 3.5 | 34.5 ±3.5 | 24.5 ± 1.9 | 28.0 ± 1.5 |
| % PRV+ cells co-expressing WFA | 74.0 ±3.1 | 71.7 ±5.9 | 63.7 ± 7.5 | 65.9 ± 10.1 |
| % PRV+ cells co-expressing c-Fos | 39.7 ±6.6 | 34.5 ±4.7 | 50.0 ± 7.3 | 55.7 ± 2.2 |
| % WFA+ cells co-expressing c-Fos | 45.9 ±8.5 | 46.8 ±8.3 | 29.8 ± 3.1 | 36.1 ± 1.7 |
| IL | 45 min | 72 hr | ||
| Saline | Nicotine | Saline | Nicotine | |
| # PRV+ cells | 22.8 ±0.7 | 21.2 ±0.9 | 13.0 ± 1.0 | 15.1 ± 1.4 |
| # WFA+ cells | 10.2 ±0.8 | 10.6 ±1.2 | 9.3 ± 1.3 | 10.3 ± 0.8 |
| # c-Fos+ cells | 33.7 ±2.0 | 37.3 ±3.0 | 20.8 ± 1.7 | 27.6 ± 1.4 |
| % PRV+ cells co-expressing WFA | 69.8 ±4.3 | 67.2 ±4.5 | 72.2 ± 8.8 | 70.5 ± 10.3 |
| % PRV+ cells co-expressing c-Fos | 37.6 ±4.3 | 30.7 ±4.8 | 64.6 ± 7.5 | 56.4 ± 6.9 |
| % WFA+ cells co-expressing c-Fos | 41.3 ±3.0 | 30.2 ± 6.5 | 45.9 ± 6.2 | 38.2 ± 4.0 |
*
p<0.05 compared to saline control.