Table 3.
Estimates for effects of time, age, and time x age interactions
| Test | Time | Age | Time x Age | ||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| β (SE) | p | r | β (SE) | p | r | β (SE) | p | r | |
|
|
|||||||||
| Cognitive | |||||||||
| Trail Making Test, Part Aa | −.272 (.085) | .002 | −.409 | .269 (.096) | .006 | .288 | −.119 (.088) | .183 | −.187 |
| Trail Making Test, Part Ba | −.124 (.057) | .034 | −.334 | .413 (.090) | <.001 | .483 | −.101 (.059) | .096 | −.264 |
| BACS Symbol-Coding | .085 (.068) | .213 | .169 | −.286 (.105) | .008 | −.255 | −.020 (.071) | .780 | −.039 |
| Letter Fluency | .084 (.066) | .205 | .183 | −.240 (.108) | .029 | −.214 | −.024 (.069) | .731 | .051 |
| Category Fluency | .067 (.097) | .492 | .109 | −.318 (.120) | .009 | −.271 | −.280 (.101) | .008 | −.392 |
| CPT-IP | .050 (.062) | .428 | .122 | −.125 (.106) | .244 | −.129 | .103 (.066) | .128 | .239 |
| UM Letter Number Span | .037 (.071) | .600 | .085 | −.298 (.107) | .007 | −.280 | .085 (.073) | .255 | .185 |
| WMS-III Spatial Span | .141 (.087) | .113 | .206 | −.390 (.114) | .001 | −.322 | .020 (.091) | .824 | .030 |
| BVMT-R Immediate recall | .341 (.076) | <.001 | .564 | −.505 (.098) | <.001 | −.493 | −.053 (.079) | .505 | −.103 |
| HVLT-R Immediate recall | .324 (.078) | <.001 | .467 | −.104 (.110) | .349 | −.096 | .149 (.082) | .079 | .231 |
| MIST Summary score | .148 (.078) | .062 | .258 | −.259 (.098) | .009 | −.260 | .043 (.081) | .600 | .075 |
| NAB Mazes | .166 (.068) | .018 | .330 | −.521 (.098) | <.001 | −.490 | −.016 (.071) | .823 | −.033 |
| WCST-64 Total Errorsa | .012 (.076) | .879 | .021 | .254 (.111) | .025 | .231 | .001 (.079) | .992 | .000 |
| Global Deficit Scorea | −.111 (.046) | .020 | −.358 | .350 (.101) | .001 | .345 | −.075 (.048) | .125 | −.241 |
| Functional Capacity | |||||||||
| UPSA Total | .200 (.098) | .047 | .255 | −.180 (.105) | .090 | −.195 | −.106 (.103) | .307 | −.136 |
| Financial subscale | .086 (.084) | .314 | .135 | −.209 (.089) | .022 | −.276 | −.194 (.087) | .031 | −.288 |
| Communication subscale | .204 (.115) | .083 | .214 | −.108 (.108) | .319 | −.119 | −.003 (.120) | .981 | −.003 |
| SSPA Mean | −.037 (.074) | .627 | −.067 | −.057 (.100) | .574 | −.058 | .048 (.077) | .539 | .085 |
| ILSS Mean | −.105 (.054) | .056 | −.185 | −.071 (.082) | .394 | −.103 | .118 (.058) | .043 | .192 |
| Quality of Life | |||||||||
| QOLI-Life in General | .009 (.046) | .843 | .020 | −.060 (.107) | .579 | −.062 | .021 (.050) | .672 | .042 |
| Symptom Severity | |||||||||
| HAM-Da | −.075 (.053) | .161 | −.132 | .031 (.108) | .773 | .032 | −.111 (.058) | .056 | −.178 |
| PANSS Positivea | −.031 (.043) | .478 | −.082 | −.115 (.108) | .290 | −.116 | −.109 (.047) | .022 | −.255 |
| PANSS Negativea | .053 (.050) | .289 | .109 | .062 (.091) | .500 | .077 | −.073 (.054) | .180 | −.135 |
Denotes measures in which lower scores are better.
BACS=Brief Assessment of Cognition in Schizophrenia; CPT-IP=Continuous Performance Test—Identical Pairs; UM=University of Maryland; WMS-III=Wechsler Memory Scale-3rd edition; BVMT-R=Brief Visual Memory Test-Revised; HVLT-R=Hopkins Verbal Learning Test-Revised; MIST=Memory for Intentions Screening Test; NAB=Neuropsychological Assessment Battery; WCST-64=Wisconsin Card Sorting Test 64-item version; UPSA=University of California, San Diego Performance-Based Skills Assessment; SSPA=Social Skills Performance Assessment; ILSS=Independent Living Skills Survey; QOLI=Quality of Life Interview; HAM-D=Hamilton Depression Rating Scale; PANSS=Positive and Negative Syndrome Scale