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. Author manuscript; available in PMC: 2017 Mar 3.
Published in final edited form as: Oncogene. 2016 Aug 22;36(9):1245–1255. doi: 10.1038/onc.2016.290

Figure 6.

Figure 6

LKB1 inhibits HK-II and glycolysis via the suppression of c-MYC. (a) Whole cell extracts were isolated from MEFs transduced with GFP or HPV16 E6/7. Thirty microgram proteins from WCEs were used for immunoblots. GAPDH serves as a loading control. (b) HeLa/pMEP4-LKB1 cells were induced with 100 μM zinc for the indicated duration. WCEs were isolated for immunoblots. (c-f) TC-1/shR-Ctrl and TC-1/shR-LKB1 cells were transfected with a smart pool of c-MYC siRNA duplexes for 72 h. (c) Immunoblot detection; (d) extracellular glucose; (e) extracellular lactate; (f) intracellular ATP. The data in d-f were the average ± S.D. from 3 independent experiments (*P < 0.01).