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. 2017 Feb 23;11:42. doi: 10.3389/fncel.2017.00042

FIGURE 1.

FIGURE 1

S100B and Sox10 expression in the developing ENS of Wnt1-CRE;R26R-GCaMP3 mice. Representative images of the myenteric plexus in the duodenum at E14.5 (A), E16.5 (B), and P0 (C). A small number of S100B-immunoreactive ENCCs are present in the duodenum at E14.5, which are all Sox10+ (arrows). At E16.5, a small population of S100B+ cells are not immunoreactive for Sox10 (arrowheads). Scale bar = 20 μm for all. The proportions of S100B+/GFP+ ENCCs (D) and Sox10+/GFP+ ENCCs (E) in the duodenum and colon at different ages. The proportion of S100B+ ENCCs increased during development and in general, was higher in the duodenum than the colon at each age. The proportion of Sox10+ ENCCs in the duodenum remains similar between E14.5 and P0, but decreases in the colon. Cell counts were made from n = 4 gut preparations for E14.5 (duodenum total of 914 GFP+ cells; colon 700), n = 3 for E16.5 (duodenum 503 GFP+ cells; colon 517), and n = 3 for P0 (duodenum 1744 GFP+ cells; colon 2614).