Figure 1.

The study design protocol. Functional and structural magnetic resonance imaging (fMRI and sMRI, respectively) was performed throughout the treatment period. All scanning was done in the morning. On day 1, participants came in for an fMRI scan (Baseline) and then were given a placebo following the scan. On day 2 (~12 h after placebo), they returned for another fMRI scan (Placebo) and then were started on venlafaxine following the scan. They returned the next day (~12 h later) for another fMRI scan (Day 1, that is, day 1 of treatment). They continued on their medication as normal and came in for scans on week 1 (Week 1) and at the end of the trial (End).