Table 1. Biodistribution of radioactivity in NMRI mice after ip injections of ¹¹¹In-DOTA-3A3 (40 μg and 160 μg – single injection, 40 μg repeated – 40 μg of non-labelled 3A3 were injected ip 24 h before ¹¹¹In-DOTA-3A3).

	6 h*	24 h*	48 h*	72 h*	168 h*	24 h**
	40 μg					40 μg repeated	160 μg
Blood	7.9 ± 0.7	1.64 ± 0.02a	0.32 ± 0.04a	0.11 ± 0.01a	0.022 ± 0.010a	1.4 ± 0.2	1.8 ± 0.3
Lung	4.3 ± 0.6	3.7 ± 0.4	1.9 ± 0.2a	1.2 ± 0.1a	0.27 ± 0.04a	1.4 ± 0.3c	1.6 ± 0.2c
Liver	6.2 ± 0.9	6 ± 1	5.37 ± 0.09	4.58 ± 0.08a	1.07 ± 0.05a	2.7 ± 0.5c	3.1 ± 0.6c
Spleen	4.6 ± 0.7	7 ± 2	7.0 ± 0.6a	6 ± 2a	4 ± 1a	1.63 ± 0.03c	1.7 ± 0.4c
Kidneys	24 ± 3	17.1 ± 0.9	13.4 ± 0.5a	10 ± 1a	2.5 ± 0.2a	38 ± 5d	42 ± 5d
Muscle	0.9 ± 0.2	0.68 ± 0.03a	0.42 ± 0.03a	0.31 ± 0.03a	0.10 ± 0.02a	0.40 ± 0.04c,e	0.49 ± 0.03c
Bone	1.7 ± 0.1	2.2 ± 0.2b	1.58 ± 0.06	1.1 ± 0.3	0.49 ± 0.05	0.8 ± 0.1c	1.0 ± 0.2c
GI tract***	14 ± 2	10 ± 2a	6.8 ± 0.6a	4.8 ± 0.4a	1.46 ± 0.09a	3.9 ± 0.4c	2.0 ± 0.1c
Carcass***	30.5 ± 0.8	25.4 ± 0.9a	18 ± 1a	12.4 ± 0.5a	4.0 ± 0.2a	35 ± 3d	34.8 ± 1.0d

Results are presented as average of percent injected dose per gram tissue (%ID/g) for 4 animals ± SD. *Data were assessed by an unpaired, two-tailed t-test in order to determine significant differences (p < 0.05). **Data were analysed together with data for 24 h using one-way ANOVA with Bonferroni correction for multiple comparisons (family-wise significance 0.05). ***Values for GI (gastrointestinal) tract and carcass are given as %ID per whole sample. ^aValue is significantly lower than for the previous time point. ^bValue is significantly higher than for the previous time point. ^cValue is significantly lower than for 24 h pi of single dose of 40 μg (at least **P ≤ 0.01). ^dValue is significantly higher than for 24 h pi of single dose of 40 μg (at least **P ≤ 0.01) e - value is significantly lower than for 24 h pi of single dose of 160 μg (*P ≤ 0.01).