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. 2017 Feb 23;7:43118. doi: 10.1038/srep43118

Table 2. Biodistribution of 111In-DOTA-3A3 and 111In-DOTA-TAT in Balb/c nu/nu mice bearing BxPC-3 xenografts 24 h after iv injections with 40 μg of conjugates.

  Radioactivity uptake
111In-DOTA-3A3 111In-DOTA-TAT
Blood 0.6 ± 0.2 4.6 ± 0.3a
Salivary glands 3.0 ± 0.2a 1.5 ± 0.2
Lung 1.7 ± 0.2 2.6 ± 0.2a
Liver 14.6 ± 1.0 18.5 ± 0.8a
Spleen 4 ± 2 14 ± 3a
Stomach 1.2 ± 0.5a 0.59 ± 0.05
Small intestine wall 6 ± 1a 0.8 ± 0.1
Kidney 30 ± 4a 20 ± 2
Tumour 5.3 ± 0.7a 2.4 ± 0.2
Muscle 0.5 ± 0.1 0.50 ± 0.04
Bone 1.2 ± 0.3a 0.86 ± 0.10
GIb 5.8 ± 0.3a 1.4 ± 0.3
Carcassb 16.6 ± 0.3a 13 ± 1
  Tumour to organ ratio
Tumour/blood 10 ± 2a 0.52 ± 0.05
Tumour/muscle 12 ± 3a 4.9 ± 0.5

Results for radioactivity uptake in tissues are presented as average of percent injected dose per gram tissue (%ID/g) for 4 animals ± SD. Data were assessed by an unpaired, two-tailed t-test in order to determine significant differences (P < 0.05). aValue is significantly higher bValues for GI (gastrointestinal) tract and carcass are given as %ID per whole sample.