Table 2. Biodistribution of 111In-DOTA-3A3 and 111In-DOTA-TAT in Balb/c nu/nu mice bearing BxPC-3 xenografts 24 h after iv injections with 40 μg of conjugates.
Radioactivity uptake | ||
---|---|---|
111In-DOTA-3A3 | 111In-DOTA-TAT | |
Blood | 0.6 ± 0.2 | 4.6 ± 0.3a |
Salivary glands | 3.0 ± 0.2a | 1.5 ± 0.2 |
Lung | 1.7 ± 0.2 | 2.6 ± 0.2a |
Liver | 14.6 ± 1.0 | 18.5 ± 0.8a |
Spleen | 4 ± 2 | 14 ± 3a |
Stomach | 1.2 ± 0.5a | 0.59 ± 0.05 |
Small intestine wall | 6 ± 1a | 0.8 ± 0.1 |
Kidney | 30 ± 4a | 20 ± 2 |
Tumour | 5.3 ± 0.7a | 2.4 ± 0.2 |
Muscle | 0.5 ± 0.1 | 0.50 ± 0.04 |
Bone | 1.2 ± 0.3a | 0.86 ± 0.10 |
GIb | 5.8 ± 0.3a | 1.4 ± 0.3 |
Carcassb | 16.6 ± 0.3a | 13 ± 1 |
Tumour to organ ratio | ||
Tumour/blood | 10 ± 2a | 0.52 ± 0.05 |
Tumour/muscle | 12 ± 3a | 4.9 ± 0.5 |
Results for radioactivity uptake in tissues are presented as average of percent injected dose per gram tissue (%ID/g) for 4 animals ± SD. Data were assessed by an unpaired, two-tailed t-test in order to determine significant differences (P < 0.05). aValue is significantly higher bValues for GI (gastrointestinal) tract and carcass are given as %ID per whole sample.