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. 2017 Feb 13;7:42398. doi: 10.1038/srep42398

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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(a) Ratio images of hiPSC-CMs expressing LOTUS-V before and during contraction (n = 23). Scale bar, 50 μm. (b) Bioluminescence recording (black) overlaid on a fluorescence recording using Di-8-ANEPPS (gray) during hiPSC-CM contraction (n = 38). The power density of excitation light for Di-8-ANEPPS was 735 mW/cm². (c) APD₉₀ measured by LOTUS-V plotted against APD₉₀ measured by Di-8-ANEPPS. The line fitted by least squares method is shown in black. (d) Time course of the ΔR/R₀ emission ratio before and after treatment with 100 nM isoproterenol. (e,f) Evaluation of action potential morphology before and after treatment with 30 μM TTX (n = 17) (e), and 10 μM astemizole (n = 12 and 8, respectively) (f). The graphs indicate individual APD₉₀ changes upon drug treatment. Wilcoxon signed-rank test was performed. *p < 0.05; Error bars indicate mean ± s.e.m.