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. 2017 Feb 23;7:43137. doi: 10.1038/srep43137

Figure 4.

Figure 4

Effects of dezocine and morphine, given subcutaneously, on spinal levels of norepinephrine (A), serotonin (B) and dopamine (C) in neuropathic rats, induced by tight ligation of L5/L6 spinal nerves. Effects of the specific norepinephrine depletor 6-hydroxydopamine (6-OHDA), serotonin depletor p-cholrophenylalanine (PCPA) (D, E) and 5-hydroxytryptamine (5-HT) receptor antagonist metergoline (F,G), given intrathecally, on dezocine and morphine mechanical antiallodynia in neuropathy. Data are presented as means ± SEM (n = 6 in each group). *P < 0.05 vs. the normal saline control or respective normal saline + dezocine and normal saline + morphine group, by one-way or repeats-measured two-way ANOVA followed by post-hoc student-Newman-Keuls tests.