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. 2017 Feb 23;7:43137. doi: 10.1038/srep43137

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Copyright © 2017, The Author(s)

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Mechanical antiallodynic tolerance development of dezocine, morphine and their combination, given subcutaneously, in neuropathic rats, induced by tight ligation of L5/L6 spinal nerves (A). Effects of the specific norepinephrine depletor 6-hydroxydopamine (6-OHDA), serotonin depletor p-cholrophenylalanine (PCPA) (B,C), and the selective noradrenergic α₁-adrenoceptor antagonist prazosin and α₂-adrenoceptor receptor antagonist yohimbe (D), given intrathecally, on dezocine and morphine antinociceptive tolerance in neuropathy. Data are presented as means ± SEM (n = 6 in each group). *P < 0.05 vs. the normal saline control or respective normal saline + 6-OHDA and normal saline + PCPA group, by repeats-measured two-way ANOVA followed by post-hoc student-Newman-Keuls tests.