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. 2017 Feb 23;7:43052. doi: 10.1038/srep43052

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Copyright © 2017, The Author(s)

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(A) Representative macroscopic views of the stomachs of Nrdc^+/+ and Nrdc^−/− mice with forced expression of PGE₂ by the insertion of K19-C2mE alleles. (B) H&E staining of Nrdc^+/+ and Nrdc^−/− mouse stomachs with forced expression of PGE₂. Bars = 1000 μm. (C) Mucosal thickness of the Nrdc^+/+ and Nrdc^−/− mice with forced PGE₂ expression. *P < 0.05. (D) Immunohistochemistry for Gr1 and F4/80 in Nrdc^+/+ and Nrdc^−/− mice. Bars = 100 μm. (E) Numbers of epithelial cells immunostained for Gr1 and F4/80 in Nrdc^+/+ and Nrdc^−/− mice. *P < 0.05. (F) mRNA expression of Cxcl1 and IL-1β in the gastric mucosae of Nrdc^+/+ and Nrdc^−/− mouse stomachs. *P < 0.05.