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. 2017 Feb 23;7:43052. doi: 10.1038/srep43052

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(A) Ki67 immunostaining in Nrdc^+/+ and Nrdc^−/− mouse stomachs with the forced PGE₂ expression. Bars = 50 μm. (B) Macroscopic views of the stomachs of Nrdc^+/+ and Nrdc^−/− mice treated with N-methyl-N-nitrosourea (MNU). (C) H&E staining of gastric tumor in Nrdc^+/+ mouse. Bars = 200 μm (left) and 20 μm (right). (D) Polyp number in the stomachs of Nrdc^+/+ and Nrdc^−/− mice treated with MNU. *P < 0.05. (E) Polyp volume of Nrdc^+/+ and Nrdc^−/− mouse gastric tumors established by MNU treatment. *P < 0.05.