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. 2017 Feb 23;7:43264. doi: 10.1038/srep43264

Figure 1. Rare variant point mutations within human CaMKK2 located close to regulatory phosphorylation sites.

Figure 1

Linear schematic of CaMKK2 domain structure showing the regulatory phosphorylation sites, kinase domain and overlapping autoinhibitory (AID) and calmodulin-binding (CaMBD) domains. Amino acid sequences (residues 80–93 and residues 124–142) show the location of rare variant point mutations (G87R, R91W, S137L, P138S, R139W, R142W) with respect to the regulatory Thr85 autophosphorylation and Ser129/Ser133/Ser137 phosphorylation sites.