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. 2017 Feb 23;7:43219. doi: 10.1038/srep43219

Figure 6. Potential role of myoglobin in cardiac fatty acid metabolism.

Figure 6

The heart is supplied with fatty acids (FA) derived from plasma FAs bound to albumin or incorporated in very-low-density lipoproteins (VLDL) triacylglycerols (TAG) or chylomicrons. The uptake occurs via diffusion or CD36/FATP transporters. Within the cytosol FAs are converted to FA acyl CoA by fatty acyl coA synthetases (FACS). The majority of FA acyl CoA is then channeled to carnitine palmitoyltransferase (CPT) system mediated by myoglobin (Mb). Converted to acylcarnitine by CPT1 FAs are translocated into the mitochondrial matrix, where they are converted back to fatty acyl CoA by CPT 2 to enter the β-oxidation cycle. A minor portion of FA acyl CoA is converted to TAG under the control of Mb.