Table 1.
Allelic association of 14 SNPs related to BCL11A, HBS1L-MYB, and HBG2 promoter region in patients with β-thalassemia and controls.
| SNP ID | Candidate gene | Chromosome position | Alleles (EA/OA) | Case versus control | ||
|---|---|---|---|---|---|---|
| χ 2 | Odds ratio (95% CI) | p value | ||||
| rs2071348 | HBG2 region | 11:5242916 | T/G | 1.184 | 0.832 (0.598–1.159) | 0.277 |
| rs7482144 | HBG2 region | 11:5254939 | C/T | 0.498 | 0.881 (0.620–1.252) | 0.480 |
| rs5006884 | HBG2 region | 11:5352021 | T/C | 1.222 | 0.818 (0.577–1.168) | 0.269 |
| rs766432 | BCL11A | 2:60492835 | A/C | 0 | 0.999 (0.719–1.388) | 0.997 |
| rs11886868 | BCL11A | 2:60493111 | T/C | 1.637 | 0.821 (0.607–1.111) | 0.201 |
| rs4671393 | BCL11A | 2:60493816 | G/A | 0.006 | 0.987 (0.709–1.375) | 0.940 |
| rs7557939 | BCL11A | 2:60494212 | A/G | 2.055 | 0.802 (0.592–1.085) | 0.152 |
| rs28384513 | HBS1L-MYB | 6:135055071 | G/T | 2.496 | 0.741 (0.511–1.075) | 0.114 |
| rs9376090 | HBS1L-MYB | 6:135090090 | C/T | 11.053 | 0.406 (0.235–0.700) | 0.0009∗ |
| rs9399137 | HBS1L-MYB | 6:135097880 | C/T | 7.228 | 0.473 (0.271–0.824) | 0.008∗ |
| rs4895441 | HBS1L-MYB | 6:135105435 | G/A | 8.785 | 0.449 (0.262–0.771) | 0.004∗ |
| rs9389269 | HBS1L-MYB | 6:135106021 | C/T | 7.096 | 0.495 (0.293–0.837) | 0.008∗ |
| rs9402686 | HBS1L-MYB | 6:135106679 | A/G | 7.096 | 0.495 (0.293–0.837) | 0.008∗ |
| rs9494142 | HBS1L-MYB | 6:135110502 | C/T | 9.936 | 0.459 (0.280–0.751) | 0.002∗ |
∗Significant association p values (p < 0.05) for the allelic model. EA: effect allele tested for association; OA: other allele; p: p value unadjusted; chromosome position as per GRCh38.p2 Assembly.