Table 1.
Overview of selected candidate miRNAs: Previously reported role(s) in hair biology and expression status of the analysed miRNAs in the human hair follicle (HF)
| Candidate miRNA | Reported role in hair biology | Reference | Mature form on miRNA array | HF Expression | # of uniquely correlated genes |
|---|---|---|---|---|---|
| miR-31 | Inhibits anagen development by regulating gene expression programmes and alters hair shaft formation in mice | Mardaryev AN et al., 2010 | hsa-miR-31-5p | ✓ | 99 |
| hsa-miR-31-3p | ✓ | - | |||
| miR-24 | Overexpression is associated with reduced proliferation and premature HF-keratinocyte differentiation in mice | Amelio I et al., 2013 | hsa-miR-24-3p | ✓ | 103 |
| hsa-miR-24-1-5p | ✓ | - | |||
| hsa-miR-24-2-5p | ✓ | 5 | |||
| miR-106a | Upregulated in balding human DPC in comparison to nonbalding DPCs | Goodarzi HR et al., 2012 | hsa-miR-106a-5p | ✓ | 53 |
| hsa-miR-106a-3p | ✗ | - | |||
| miR-22 | Overexpression in mice is associated with hair loss due to anagen-to-catagen transition and knockout in mice is associated with delayed catagen entry and accelerated telogen-to-anagen transition | Yuan S et al., 2015 | hsa-miR-22-5p | ✓ | - |
| hsa-miR-22-3p | ✓ | ||||
| miR-125b | Represses HF stem cell differentiation in mice; significantly upregulated in balding human DPCs in comparison to nonbalding DPCs | Zhang L et al., 2011; Goodarzi HR et al., 2012 | hsa-miR-125b-5p | ✓ | – |
| hsa-miR-125b-1-3p | ✗ | ||||
| hsa-miR-125b-2-3p | ✓ | ||||
| miR-137 | Involved in murine HF pigmentation (melanogenesis) | Dong C et al., 2012 | hsa-miR-137 | ✗ | – |
| miR-205 | Essential for development of HF stem cell proliferation during murine embryonic skin development | Wang D et al., 2013 | hsa-miR-205-5p | ✓ | – |
| hsa-miR-205-3p | ✓ | ||||
| miR-214 | Controls Wnt pathway and β-catenin expression in murine embryonic HF development | Ahmed MI et al., 2014 | hsa-miR-214-5p | ✗ | – |
| hsa-miR-214-3p | ✗ | ||||
| miR-221 | Upregulated in balding human DPCs in comparison to nonbalding DPCs | Goodarzi HR et al., 2012 | hsa-miR-221-5p | ✓ | – |
| hsa-miR-221-3p | ✓ | 1 | |||
| miR-410 | Upregulated in balding human DPC in comparison to nonbalding DPCs | Goodarzi HR et al., 2012 | hsa-miR-410-5p | ✗ | – |
| hsa-miR-410-3p | ✗ |
HF hair follicle, DPCs dermal papilla cells, # number