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. 2017 Feb 23;16:44. doi: 10.1186/s12943-017-0610-2

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — ITIH5 expression loss in breast cancer subtypes and distant metastases. a-b Illustration of ITIH5 mRNA expression based on the TCGA data portal. a Box plot demonstrating a significant loss of ITIH5 mRNA expression in primary breast tumors and distant metastases derived from primary breast tumors, ns: not significant, ***p < 0.001. b Breast tumor samples stratified by subtypes [28], ns: not significant, **p < 0.01; ***p < 0.001. c-d Kaplan-Meier analyses display OS of nodal-negative (pN0, c) and non-metastatic (pM0, d) breast cancer patients stratified by high ITIH5 (green curve) and low/intermediate ITIH5 mRNA expression (blue curve)