Fig. 6.

Tumor suppressing effects of MSC-Tandab in combination with D-1MT against B cell lymphoma in mice. a Histological analysis in organs from mice. On day 7 after treatment, mice organs including the lung, liver, spleen, and kidney were dissociated for fixation and HE staining. Scale bar = 100 μm. b Experimental protocol of the tumor therapy. BALB/c nude mice were injected subcutaneously with Raji cells (2 × 10⁷ per mouse) into the right flank. Seven days later (day 0), MSCs (1 × 10⁶ per mouse) were injected intravenously into the xenograft Raji tumor-bearing mice. Mice received intravenous injection of PBMCs (5 × 10⁶ per mouse) on day 2. And mice were treated with or without D-1MT (2 mg/mL in the drinking water) along the treatment. The second treatment was received on day 7. All mice were sacrificed on day 21. c The tumor weights of different groups were measured in the end of treatment. d Changes in the body weight of Raji lymphoma xenograft models during the treatment. NS, no significance; **P<0.01; ***P<0.001