Figure 2.

Structures of ARBDs. (A) The ARBDs shown include a macrodomain from Archaeoglobus fulgidus Af1521 (Protein Data Bank [PDB] 2BFQ), a WWE domain from human RNF146 (PDB 3V3L), and a PBZ motif from human CHFR (PDB 2XOY). The ARBDs are shown in blue, and the ADP-ribose ligands are highlighted in red. (B) Schematic showing the structures of example proteins containing ARBDs: human PARG (macrodomain), human RNF146 (WWE domain), and human CHFR (PBZ motif). The different domains in the proteins are indicated.