Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jan 15;31(2):101–126. doi: 10.1101/gad.291518.116

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 Gupte et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

Figure 5. — PARP monoenzymes and catalytically inactive PARPs participate in diverse biological processes. (A) PARP-16 regulates the UPR by modulating PERK and IRE1α activity. (B) PARP-10 attenuates NF-κB signaling by inhibiting NEMO. (C) PARP-6 is required for neurogenesis in the hippocampus. (D) PARP-13 inhibits viral pathogens by promoting TRAIL-mediated apoptosis, accumulation of cytotoxic transcripts, and inhibition of retroviral mRNA production. (E) PARP-9 associates with deltex E3 ubiquitin ligase 3L (DTX3L). Together, they promote antiviral gene transcription and trigger degradation of viral 3C proteases. (F) The macroPARPs PARP-14 and PARP-15 are involved in host–virus conflicts via their rapidly evolving macrodomains. See the text for details.