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. 2017 Jan 15;31(2):172–183. doi: 10.1101/gad.290635.116

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© 2017 Ritschka et al.; Published by Cold Spring Harbor Laboratory Press

This article, published in Genes & Development, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 4. — Loss of SASP regulator NFκB in senescent cells causes a decrease in stem cell gene expression. (A) qPCR analysis of Ras- and shp16 I-double-infected keratinocytes at 6, 10, and 14 dpi normalized to Ras- and vector-double-infected keratinocytes on the respective days. n = 3. (B,C) Representative colony-forming assay (B) and number of colonies (C) of Ras- and vector-double-infected and Ras- and shp16 II-double-infected keratinocytes at 14 dpi. n = 4. (D) qPCR analysis of Ras- and shRelA II-double-infected keratinocytes at 6, 10, and 14 dpi normalized to Ras- and vector-double-infected keratinocytes on the respective days. n = 3. (E) The number of α6-integrin⁺/CD34⁺ cells of Ras, shRelA I, shRelA II, and NFκB superrepressor (SR)-double-infected keratinocytes normalized to Ras- and vector-double-infected keratinocytes at 10 dpi. n = 3. (A,C,D,E) Error bars indicate mean ± SEM. (*) P < 0.05; (**) P < 0.01; (***) P < 0.001, two-tailed Student's t-test.