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. 2017 Feb 17;11:451–461. doi: 10.2147/DDDT.S129991

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© 2017 Liang et al. This work is published and licensed by Dove Medical Press Limited

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The RMSD of heavy atoms for all systems and superimposition the initial structure and the last snapshot from classical MD simulations.

Notes: (A) Time evolution of the RMSD of FGFR1^WT and AZD4547; (B) superimposition the initial structure (green) and the last snapshot (purple) of FGFR1^WT/AZD4547; (C) time evolution of the RMSD of FGFR1^V561M and AZD4547; (D) superimposition the initial structure (green) and the last snapshot (purple) of FGFR1^V561M/AZD4547; (E) time evolution of the RMSD of FGFR1^WT and E3810; (F) superimposition the initial structure (green) and the last snapshot (purple) of FGFR1^WT/E3810; (G) time evolution of the RMSD of FGFR1^V561M and E3810; (H) superimposition the initial structure (green) and the last snapshot (purple) of FGFR1^V561M/E3810.

Abbreviations: FGFR1, fibroblast growth factor receptor 1; MD, molecular dynamics; RMSD, root mean square deviation; WT, wild type.