Table II.
Top 10 Differentially Methylated Probes from EWAS Analysis based on HOMA-IR
| CpG Probe | Chromosome | Gene | Base pair | Feature | Log2 Fold Change | Original P- value | Bonferroni Corrected P- value |
|---|---|---|---|---|---|---|---|
| cg25329211 | 2 | NA | 64375257 | IGR – Shelf | −0.004 | 4.56E-08 | 0.01 |
| cg10171063 | 12 | FAR2 | 29302232 | Exon 1 - Island | −0.005 | 6.98E-08 | 0.02 |
| cg12503835 | 8 | TSNARE1 | 143324660 | Body – Open Sea | −0.02 | 1.69E-07 | 0.06 |
| cg04488853 | 11 | CCKBR | 6293288 | 3′UTR - shore | −0.02 | 2.49E-07 | 0.08 |
| cg10902825 | 12 | FAR2 | 29302179 | Exon1 - Island | −0.005 | 2.57E-07 | 0.09 |
| cg11390073 | 12 | FAR2 | 29302515 | Intron 1 - Island | −0.009 | 3.00E-07 | 0.10 |
| cg24677744 | 12 | FAR2 | 29302016 | Exon1 - Island | −0.008 | 3.01E-07 | 0.10 |
| cg20697767 | 17 | RPRML | 45056325 | Exon 1 - Island | 0.02 | 3.41E-07 | 0.12 |
| cg21725878 | 12 | NA | 132956918 | IGR – Island | −0.01 | 3.86E-07 | 0.13 |
| cg15076218 | 1 | PIK3R3 | 46599002 | TSS1500 - island | 0.01 | 4.02E-07 | 0.14 |
Lists the top 10 differentially methylated probes (CpG probes) from the EWAS analysis based on HOMA-IR while adjusting for age, race, gender, AAP group, smoking, folate, BMI and cellular composition. Location, gene (if applicable), feature of probe and Log2 Fold Change are listed along with original and Bonferroni adjusted p-values. The top two hits remained significant after multiple testing correction.