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. 2017 Feb 23;12(2):e0171690. doi: 10.1371/journal.pone.0171690

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© 2017 Ali et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 4 — a) Complete Linkage Hierarchical clustering of 116 cases with CRC. The generated 5-clusters are depicted in the dendogram. The lower panels show microsatellite stability and BRAF gene status. b) Frequency (aggregate) histograms from 5-groups of CRCs clustered according to copy number aberration patterns. The upper histogram represents the summation of all the aberrations in 116 cases of CRC. Deviations up from 0% (Log2 ratio) represent copy number gains and are colored blue, while deviations below the 0% line (red) represent copy number losses. The y-axis represents % of samples with a specific aberration. The two horizontal lines demarcate the cutoff (35%) used to call aberrations in the STAC algorithm. The lower histograms are aberrations found in the 5 generated clusters.