Table 6. Copy number aberrations generated by the GISTIC algorithm in MSI CRC.
| Narrow Region* | Extended Region | Type | Q-Bound | G-Score |
|---|---|---|---|---|
| chr6:32,576,786–32,603,160 | chr6:32,563,052–32,644,260 | Loss | 4.82E-12 | 12.7 |
| chr8:39,349,089–39,359,852 | chr8:39,349,089–39,365,809 | Loss | 8.29E-09 | 10.7 |
| chr22:22,669,244–22,717,333 | chr22:22,645,114–22,722,828 | Loss | 1.42E-06 | 8.5 |
| chr14:19,487,351–19,493,856 | chr14:18,753,436–19,493,856 | Loss | 5.47E-06 | 7.9 |
| chr1:149,367,733–149,397,162 | chr1:149,367,733–149,397,162 | Loss | 6.95E-06 | 7.8 |
| chr1:193,475,381–193,529,957 | chr1:193,456,932–193,544,824 | Loss | 4.26E-05 | 7.2 |
| chr14:105,589,128–105,636,720 | chr14:105,589,128–105,636,720 | Loss | 4.26E-05 | 7.2 |
| chr11:55,115,301–55,191,165 | chr11:55,115,301–55,216,250 | Gain | 0.002372 | 7.1 |
| chr15:19,501,226–19,796,337 | chr15:19,351,570–20,150,205 | Loss | 4.26E-05 | 7.1 |
| chr3:60,339,210–60,409,611 | chr3:60,339,210–60,731,181 | Loss | 1.92E-04 | 6.6 |
| chr8:7,258,853–7,953,633 | chr8:267,005–8,144,283 | Loss | 2.44E-04 | 6.5 |
| chr6:245,716–327,686 | chr6:245,716–327,686 | Loss | 5.65E-04 | 6.0 |
| chr4:69,295,525–69,550,743 | chr4:69,127,903–69,550,743 | Loss | 0.001436 | 5.5 |
| chr1:18,197,094–18,292,586 | chr1:18,175,101–18,292,586 | Loss | 0.001436 | 5.5 |
| chr18:33,269,571–33,343,946 | chr18:31,514,045–42,919,686 | Loss | 0.00465 | 4.8 |
| chr11:134,210,403–134,452,384 | chr11:133,657,612–134,452,384 | Loss | 0.011382 | 4.4 |
| chr16:54,349,083–54,384,952 | chr16:52,708,563–54,384,952 | Loss | 0.012709 | 4.3 |
| chr21:13,591,226–14,355,692 | chr21:13,572,244–14,355,692 | Loss | 0.015794 | 4.1 |
| chr12:130,314,128–130,408,894 | chr12:129,946,814–130,706,577 | Loss | 0.018008 | 4.1 |
| chr7:141,962,422–141,981,657 | chr7:141,148,142–158,628,139 | Loss | 0.019226 | 4.0 |
| chr9:42,913,008–43,080,383 | chr9:42,913,008–43,080,383 | Loss | 0.019226 | 4.0 |
| chr20:57,698,990–57,804,320 | chr20:57,664,611–57,848,527 | Loss | 0.027869 | 3.8 |
| chr11:5,735,996–5,764,428 | chr11:4,455,169–6,584,397 | Loss | 0.035934 | 3.7 |
| chr16:34,318,531–34,455,993 | chr16:34,148,509–35,005,009 | Loss | 0.040215 | 3.7 |
| chr22:46,946,978–47,684,217 | chr22:46,946,978–47,900,828 | Loss | 0.049436 | 3.5 |
*Shaded rows point to deletions private to MSI and not identified by the GISTIC algorithm as significant in the MSS CRC series.