Table 3.

Adverse effects.

Adverse effect	Ipilimumab/RT	Ipilimumab alone	p-value
N	70	31
Colitis	8 (11.4)	1 (3.2)	0.27
Hypophysitis	2 (2.8)	2 (6.4)	0.58
Dermatitis	3 (4.2)	1 (3.2)	1.00
Vitiligo	2 (2.8)	1 (3.2)	1.00
LowACTH	3 (4.2)	3 (9.6)	0.37
Low TSH	1 (1.4)	2 (6.4)	0.23
Hepatitis	1 (1.4)	0 (0)	—
Adrenalitis	1 (1.4)	0 (0)	—
Pernicious anemia	0 (0)	1 (3.2)	—

Adverse effects: Various toxicities are compared between the Ipi/RT and ipilimumab alone group to show that there was not a significantly greater risk of toxicity from the added radiotherapy in the Ipi/RT group. Values are presented as n (%) or as medians.

^*represents p < 0.05.