Table 4.
Characteristics of 123 subjects in whom RBC membrane lipids were measured. Data are mean ± SD or median (25th – 75th percentile), unless otherwise indicated. All RBC lipids are expressed as mol% of total phospholipids. The lipid mole percentages were determined by mass tandem mass spectrometry. Continuous variables were compared between groups using ANOVA adjusted for age and gender where appropriate, categorical variables - using chi-square tests. Variables with non-normal distributions were inverse-normally transformed before analysis. HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol; TG, triglyceride; PC, phosphatidylcholine; SM, sphingomyelin; PE, phosphatidylethanolamine; ePC, ether-phosphatidylcholine; PS, phosphatidylserine; LPE, lysophosphatidylethanolamine; ePE, ether-phosphatidylethanolamine; LPC, lysophosphatidylcholine; PA, phosphatidic acid.
Characteristic |
Black (n = 41) |
Hispanic (n = 82) |
P-value |
|---|---|---|---|
Age, years |
42.2 ± 11.5 |
34.8 ± 9.5 |
0.00087 |
Female, n (%) |
34 (82.9) |
55 (67.1) |
0.10 |
Male, n (%) |
7 (17.1) |
27 (32.9) |
0.10 |
fALOD4 binding (nRFU) |
1.4 (1.1–1.7) |
1.7 (1.3–2.0) |
1.3 (1.0–1.5) |
Total cholesterol (mg/dL) |
184.5 ± 38.5 |
185.2 ± 35.2 |
0.097 |
HDL-C (mg/dL) |
59.7 ± 14 |
47.9 ± 11.8 |
0.00039 |
LDL-C (mg/dL) |
107.5 ± 35.6 |
105.4 ± 29.6 |
0.35 |
TG (mg/dL) |
71 (56–101) |
130 (89–190) |
1.2E-08 |
|
RBC membrane lipids |
|||
PC (mol %) |
40 ± 2.4 |
44 ± 3.6 |
2.7E-11 |
SM (mol %) |
19 ± 4.1 |
19 ± 3.5 |
18 ± 4.4 |
PE (mol %) |
15 ± 1.8 |
12 ± 1.8 |
6.6E-07 |
ePC (mol %) |
5.7 ± 0.61 |
6.1 ± 0.92 |
0.0028 |
PS (mol %) |
6.0 ± 0.94 |
6.2 ± 1.1 |
5.9 ± 0.81 |
LPE (mol %) |
5.1 ± 1 |
4 ± 1.4 |
0.0027 |
Ceramides (mol %) |
2.9 ± 0.45 |
2.8 ± 0.57 |
0.61 |
PI (mol %) |
2.7 ± 0.63 |
2.7 ± 0.8 |
0.18 |
ePE (mol %) |
1.7 ± 0.35 |
1.3 ± 0.26 |
8.3E-06 |
LPC (mol %) |
1.4 ± 0.31 |
1.2 ± 0.29 |
2.3E-08 |
PA |
0.44 ± 0.13 |
0.38 ± 0.099 |
0.0024 |