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. 2016 Jul 28;7(40):64589–64604. doi: 10.18632/oncotarget.10905

Figure 2. mRNA expression of genes encoding for neurotrophic factors and proinflammatory markers.

Figure 2

Treatment I: Wild type (non-transgenic) control of the APPsw mice fed with regular diet; Treatment II: APPsw mice also fed with regular diet; and Treatment III: APPsw mice fed with 4% pomegranate fruit diet. The levels of two important neurotrophic factors, BDNF and IGF-1, and the proinflammatory cytokines, tnf-α, il-1β, iNOS, ccl2, and il-10, in the brains of mice fed 4% pomegranate diet for 15 months were determined using real-time polymerase chain reactions. Graphs are mean ± S.E brains from tissue obtained from six rodents for each treatment group. Significance *p < 0.01 compared to wild-type mice fed with regular diet, #p < 0.01 compared to APPsw transgenic mice fed with regular diet.