Table 2. Univariate analysis of clinical and molecular variables in oligodendroglial tumors.

		n	HR	[95%CI]	Median OS (years)	p
Gender	Male	137	1		10.1	0.18
	Female	106	0.755	[0.499 - 1.141]	11.8
Age	≤ 50 years	181	1		11.8	<0.000001
	> 50 years	62	3.289	[2.173 - 4.98]	5.9
Histologic grade	Grade II	169	1		11.8	<0.000001
	Grade III	74	3.84	[2.517-5.859]	6.7
Histologic type	Oligodendroglial	132	1		11	0.059
	Mixed oligoastrocytic	111	1.481	[0.982-2.234]	10
Frontal involvement	Yes	173	1		10.6	0.238
	No	69	1.302	[0.839 - 2.02]	7.8
Operation	Total resection	173	1		11.3	0.172
	Non-total resection	67	1.345	[0.878 - 2.059]	9.7
Adjuvant therapy	Concomitant chemo-radiotherapy	127	1		10.6	0.361
	Radiotherapy only	57	1.512	[0.867 - 2.639]	8.8
	Chemotherapy only	9	1.464	[0.869 - 2.464]	NR
	No adjuvant therapy	38	0.872	[0.21 - 3.63]	10.1
1p/19q	codeleted	143	1		11.8	<0.00001
	non-codeleted	100	2.563	[1.689 - 3.889]	7
IDH1/2	mut	195	1		10.6	0.001
	wt	25	2.553	[1.454 - 4.483]	3.8
TERTp	mut	121	1		11.1	0.053
	wt	58	1.638	[0.988 - 2.715]	10.1
mut, mutant; wt, wild-type; n, number of cases with data available.