Table 1. Clinical ophthalmic observation and analysis for the subretinal transplantation of PDMS and PDMS-PmL bioscaffold at post-implantation 6, 12, and 24 months.
Group | Post-implantation month | Cornea/Lens by Slit-Lamp examination | IOP (mmHg) by Pneumotonogram | Vitreous Media by Color fundi photography | Implant/Retina features by Color fundi photography | Implant/Retina features by OCT examination |
---|---|---|---|---|---|---|
PDMS (n=4) | 6 | Normal | 15.2 ± 2.1 | Clear | Implant in situ Retina well-looking | Implant stable Photoreceptor layer mild edema |
12 | Normal | 14.3 ± 2.3 | Clear | Implant in situ Retina whitening/atrophy | Implant stable Photoreceptor/RPE layer partial degenerated | |
24 | Normal | 15.6 ± 1.5 | Clear | Implant in situ Retina atrophy | Implant stable Photoreceptor/RPE layer partial loss | |
PDMS-PmL (n=6) | 6 | Normal | 15.1 ± 1.7 | Clear | Implant in situ Retina well-looking | Implant stable Photoreceptor/RPE layer intact |
12 | Normal | 15.7 ± 1.9 | Clear | Implant in situ Retina well-looking | Implant stable Photoreceptor/RPE layer intact | |
24 | Normal | 15.3 ± 1.8 | Clear | Implant in situ Retina well-looking | Implant stable Photoreceptor/RPE layer intact |
PDMS (n = 4 pigs); PDMS-PmL (n = 6 pigs)