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. 2016 Aug 17;7(40):65052–65066. doi: 10.18632/oncotarget.11350

Figure 1. CXCL1 expression in HCC tumor and adjacent non-tumor tissues and association with recurrence.

Figure 1

(A) Comparison of mRNA expression of CXCL1 between thirty frozen tumor tissues and paired adjacent non-tumor tissues from HCC patients (P > 0.05). (B) Low and high CXCL1 expression staining scores in HCC. Original magnification was ×50 and ×200. (C) Patients with low CXCL1 expression in HCC tissues had higher 3 year DFS rates than those with high CXCL1 expression. (D) In serum AFP < 400 ng/mL subgroup, patients with low CXCL1 expression in HCC tissues had better 3 year DFS rates than patients with high CXCL1 expression. (E) In moderately and well–differentiated tumor subgroups, patients with low CXCL1 expression had better prognosis in 3 year DFS rates than patients with high expression. (F) CXCL1 protein expression in frozen HCC tissues. (G) The level of CXCL1 protein expression in patients with recurrence at 3 years after hepatectomy was higher than those without recurrence, which was confirmed by immunoblotting (, non-parameter test). (H) The level of CXCL1 protein in perioperative serum from patients with recurrence at 3 year was higher than those without recurrence, as assessed by ELISA. *P < 0.05, **P < 0.01. Results were presented as the average (mean ± SD) representing the average of three independent experiments.