Table 1. Genes differentially expressed in hIMB cells 12 h after DUX4-plasmid transfection.
| DUX4 12 h | ||||
|---|---|---|---|---|
| FC | Gene | Description | ref | |
| 217.4 | ZSCAN4 | zinc finger and SCAN domain containing 4 | ‡ | |
| 82.3 | TRIM43 | tripartite motif containing 43 | ‡ | |
| 46.0 | PRAMEF1 | PRAME family member 1 | ‡ | |
| 42.8 | RFPL2 | ret finger protein-like 2 | ‡ | |
| 38.1 | USP29 | ubiquitin specific peptidase 29 | ‡ | |
| * | 38.0 | HPX-2 | homeobox HPX-2 | |
| 34.3 | LEUTX | leucine twenty homeobox | ||
| 33.1 | RFPL3 | ret finger protein-like 3 | ‡ | |
| 29.2 | TRIM49 | tripartite motif containing 49 | ‡ | |
| 27.6 | MBD3L2 | methyl-CpG binding domain protein 3-like 2 | ‡ | |
| 26.2 | TRIM64 | tripartite motif containing 64 | ‡ | |
| 25.0 | RFPL4B | ret finger protein-like 4B | ‡ | |
| 21.6 | SLC34A2 | solute carrier family 34 (type II sodium/phosphate contransporter). member 2 | ‡ | |
| 18.6 | RFPL1 | ret finger protein-like 1 | ‡ | |
| 15.5 | PRAMEF8 | PRAME family member 8 | ‡ | |
| * | 13.5 | DUX3 | double homeobox 3 | |
| 12.2 | PRAMEF9; PRAMEF25; PRAMEF19; PRAMEF22 | PRAME family member 9;PRAME family member 25;PRAME family member 19;PRAME family member 22 | ‡ | |
| 7.9 | FRG2 | FSHD region gene 2 | ||
| 7.5 | CXCL9 | chemokine (C-X-C motif) ligand 9 | ||
| 7.0 | TRIM51. TRIM51HP | tripartite motif-containing 51;tripartite motif-containing 51H. pseudogene | ||
| 6.7 | MRAP2 | melanocortin 2 receptor accessory protein 2 | ||
| * | 6.5 | GCG | glucagon | |
| 6.5 | ZIM3 | zinc finger. imprinted 3 | ||
| 6.2 | PRAMEF2 | PRAME family member 2 | ‡ | |
| 5.5 | FAM90A1 | family with sequence similarity 90. member A1 | ‡ | |
| 5.5 | TRIM48 | tripartite motif containing 48 | ‡ | |
| 5.5 | CCDC30 | coiled-coil domain containing 30 | ||
| * | 5.4 | CCL20 | chemokine (C-C motif) ligand 20 | |
| 4.9 | DGKE | diacylglycerol kinase. epsilon 64kDa | ||
| * | 4.8 | CXCL3 | chemokine (C-X-C motif) ligand 3 | |
| * | 4.7 | CXCL11 | chemokine (C-X-C motif) ligand 11 | |
| 4.5 | CCL3 | chemokine (C-C motif) ligand 3 | ||
| 4.5 | DHRS2 | dehydrogenase/reductase (SDR family) member 2 | ||
| * | 4.3 | CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity. alpha) | |
| 4.1 | PPP4R4 | protein phosphatase 4. regulatory subunit 4 | ||
| * | 4.0 | NR4A3 | nuclear receptor subfamily 4. group A. member 3 | |
| 4.0 | SRSF8 | serine/arginine-rich splicing factor 8 | ||
| 3.8 | TRIM63 | tripartite motif containing 63. E3 ubiquitin protein ligase | ||
| * | 3.8 | CXCL2 | chemokine (C-X-C motif) ligand 2 | |
| * | 3.8 | PTX3 | pentraxin 3. long | |
| * | 3.8 | EGR1 | early growth response 1 | |
| * | 3.5 | CXCL8 | chemokine (C-X-C motif) ligand 8 | |
| * | 3.5 | SERPINA3 | serpin peptidase inhibitor. clade A (alpha-1 antiproteinase. antitrypsin). member 3 | |
| 3.5 | KCNAB2 | potassium voltage-gated channel. shaker-related subfamily. beta member 2 | ||
| 3.4 | CCL3L3 | chemokine (C-C motif) ligand 3-like 3 | ||
| * | 3.4 | HEATR9 | HEAT repeat containing 9 | |
| * | 3.2 | TNFAIP2 | tumor necrosis factor. alpha-induced protein 2 | |
| 3.1 | TNFSF14 | tumor necrosis factor (ligand) superfamily. member 14 | ||
| * | 3.1 | KLF15 | Kruppel-like factor 15 | |
| * | 3.1 | CXCL10 | chemokine (C-X-C motif) ligand 10 | |
| * | 3.1 | CSF3 | colony stimulating factor 3 (granulocyte) | |
| ... | ... | ... | ||
| –3.6 | TNRC6C | trinucleotide repeat containing 6C | ||
| –3.8 | GFRA2 | GDNF family receptor alpha 2 | ||
| –4.4 | CACNA1F | calcium channel. voltage-dependent. L type. alpha 1F subunit | ||
| * | –5.1 | HCAR2 | hydroxycarboxylic acid receptor 2 | |
| –8.0 | RBBP8NL | RBBP8 N-terminal like | ||
Asterisk labels genes that are also differentially expressed in DUX4c-transfected IMBs.
‡
labels genes previously descried DUX4 target genes [12].