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. 2016 Aug 22;7(40):65171–65184. doi: 10.18632/oncotarget.11496

Figure 2. 4c compound reduced cell viability inducing apoptosis and cell cycle arrest in NK leukemic cells.

Figure 2

(A) Viability of KHYG1, NK92, 3 PBMCs from HDs (HDs) and NK primary cells sorted from 3 HDs (HD-NK cells) was evaluated by MTS assay after treatment with 4c compound at different concentration (2–10 μM) for 24–72 hours. Results are expressed as percent of cell viability normalized to DMSO-treated control cells. The bar-graphs represent mean with S.D. from three independent experiments. (B) Apoptosis and (C) cell cycle analysis were evaluated by flow cytometer in NK cell line after 4c or DMSO vehicle treatment at 4 μM for 24 hours. Dot plots and cell cycle histograms show a single representative experiment, the bar-graphs represent mean with S.D. from three independent experiments. P-value is indicated by asterisk: ***p < 0.001.