Figure 5. 4c treatment reduced viability and induced caspase 3-mediated apoptosis in PBMC from CLPD patients.

(A) Trypan blue count was performed in primary cells, isolated from 3 HDs and 3 CLPD patients (UNP: 6–8) and (B) Caspase 3/7 activity assay on 3 CLPD patients (UNP: 6–8) after 24 hours of treatment with 4c compound at 4 μM concentration. P-values are indicated by asterisk: *p < 0.05, **p < 0.01.