Figure 5. Dynamic changes of expression of protein in EGFR/ALK co-existing patients who received TKI.

A. After resistance to erlotinib, P-EGFR was at higher level than P-ALK. B. After resistance to crizotinib, P-EGFR was higher than P-ALK. C. Pre-EGFR-TKI, P-EGFR was higher than P-ALK. D. After resistance to erlotinib, the level of P-ALK was higher than P-EGFR. P-, phospho-. ALK, anaplastic lymphoma kinase. EGFR, epidermal growth factor receptor.TKI, tyrosine kinase inhibitor.