Figure 11. The pathways mediated by SIRT1 in NaF-induced apoptosis and autophagy.

The protein expression levels of Rab7 and Binp3 were detected to evaluate SIRT1-mediated pathways in cells treated with NaF alone, pre-incubated with SRT1720 or pre-incubated with Ex-527. (A, B) The Rab7 and Binp3 expression levels were detected using Western blot assay. (C, D) Results of densitometric analysis for Western blot.