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. 2016 Aug 25;7(40):65643–65659. doi: 10.18632/oncotarget.11595

Figure 7. Effects of HL156A and combined HL156A and TMZ treatment on xenograft tumor growth and animal survival.

Figure 7

A, B. GSC11-luc TSs were xenografted and tumors from animals treated with HL156A (35 mg/kg) or TMZ (30 mg/kg) alone, or HL156A and TMZ (45 and 30 mg/kg, respectively) in combination were assessed using bioluminescence imaging (n=5 for each group) Tumor volumes were assessed and quantified. C. Tumors from animals treated with HL156A or HL156A and TMZ showed less irregular margins than those from controls. Notably, combination treatment decreased tumor volume. Survival of animals in the combination treatment group was significantly increased (P < 0.0001).