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. 2016 Aug 25;7(40):65707–65720. doi: 10.18632/oncotarget.11604

Figure 6. Tumor growth in vivo is reduced by the combined treatment with eupafolin and TRAIL.

Figure 6

Nude mice were subcutaneously inoculated with Caki cells. Tumor volume was monitored during the following treatments: vehicle, eupafolin (10 mg/kg; i.p.), GST-TRAIL (3 mg/kg, i.p.), or eupafolin plus TRAIL for 21 days. A. The graph shows changes in the tumor volume. Number of animals per group = 7. Data are means ± SE (n=7). * p < 0.05 compared to vehicle. B. The size of the dissected-out tumors is shown. C. Representative images of tumors sections that were analyzed by TUNEL assay. Nuclear staining was performed with DAPI. D. Bodyweight changes during the experiment. E. Schematic models of eupafolin-mediated TRAIL sensitization.