Table 2. Cox regression models of patients with TSCC for clinical and pathologic factors.

Characteristic	Subcharacteristic	Univariate Analysis			Multivariate Analysis
		HR	95 % CI	P	HR	95 % CI	P
Gender	Female	1
	Male	2.206	0.983-4.950	0.055
Age(years)	<60	1
	≥60	1.008	0.977-1.040	0.611
Pathologic differentiation	Well	1
	Moderately/Poorly	1.153	0.513-2.588	0.731
Lymphoid infiltrate	Dense and continuous	1
	Discontimuous/limited	1.718	0.792-3.726	0.171
Invasive patterna	Type1/2	1
	Type3/4	1.618	0.680-3.851	0.277
Local relapse	No	1
	Yes	2.081	0.622-6.964	0.234
SUZ12 total	Low	1
	High	0.725	0.333-1.578	0.418
miR-320a TIF	Low	1
	High	0.649	0.288-1.461	0.296
Invasive depth	≤4mm	1
	>4mm	3.616	1.085-12.058	0.036
Tumor budding	Low grade	1
	High grade	2.228	0.991-5.008	0.046
SUZ12 TIF	Low	1
	High	3.311	1.432-7.658	0.005
T classification	T1/2	1			1
	T3/4	3.752	1.724-8.164	0.001	2.423	1.074-5.464	0.033
Lymph node metastasis	Negative	1			1
	Positive	3.722	1.654-8.373	0.001	3.939	1.704-9.104	0.001
miR-320a overall	Low	1			1
	High	0.433	0.200-0.939	0.034	0.367	0.161-0.837	0.017

The status of lymph node metastasis was available for only 79 patients

^aType1: broad pushing manner

Type2: broad pushing ‘fingers’ or separate large tumor islands

Type3: invasive islands of tumor greater than 15 cells per island

Type4: invasive tumor islands smaller than 15 cells per island