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. 2016 Sep 1;7(40):66003–66019. doi: 10.18632/oncotarget.11788

Figure 4. KEGG functional annotation of DE genes in cells treated with CKI.

Figure 4

Over-represented KEGG pathways for all DE genes identified from comparison of CKI treated cells with untreated cells for A. 24 hours or B. 48 hours. Red coloured nodes mean that more than 60% of DE genes that contributed to this pathway were up-regulated and green coloured nodes mean that more than 60% of DE genes that contributed to this pathway were down-regulated. The colour gradient represents the proportion of up- or down- regulated genes between these two cut offs, and node size is proportional to the significance of over-representation. Pathways with similar functional classifications are connected with edges and the most significant term in each cluster is shown in bold. Comparison of over-represented KEGG pathways for the top 200 significant DE genes in cells treated with 2 mg/mL CKI or 5-FU for C. 24 hours or D. 48 hours. Four different colours were used to represent the proportion of DE genes from up- or down- regulated genes. For CKI (red = up-regulated and green = down-regulated) or 5-FU (blue = up-regulated and yellow = down-regulated). Node size represents the significance of over-representation and terms with similar functional classifications are connected with edges and the most significant term in each cluster is shown in bold.